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Experimental drug daraxonrasib shows major benefit in pancreatic cancer trial

scienceMay 6, 202610124

The New England Journal of Medicine published phase 1/2 results showing daraxonrasib produced objective responses in up to 35% of patients with previously treated RAS‑mutant pancreatic cancer. Treatment-related grade 3 or higher adverse events occurred in 30% of patients, and investigators reported substantial extensions in overall survival compared with historical outcomes. Revolution Medicines has secured FDA clearance for an expanded access program and is advancing confirmatory testing with lead investigator Dr. Brian Wolpin, offering the first clinically meaningful RAS‑directed therapy for a disease with very limited treatment options.

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