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Personalized mRNA melanoma vaccine cuts recurrence risk in trial

scienceOct 23, 2026194,273

A personalized mRNA vaccine developed by Moderna and MSD (Merck and Co) cut the risk of melanoma recurrence or death by 42 percent in a phase 3 trial, researchers report. The investigational therapy, called intismeran, was given in combination with pembrolizumab after surgical removal of melanoma and was compared with pembrolizumab alone in 1,137 patients across 157 global sites. The vaccine is bespoke: investigators biopsy each patient’s tumor, identify the top 34 tumor-specific neoantigen differences versus healthy tissue, encode that “fingerprint” as mRNA and inject it to prime the immune system. The trial was led from Australia, with Melanoma Institute Australia’s medical director Georgina Long as principal investigator; Long called the 42 percent reduction “phenomenal” and a “foundational shift.” Results will be published in the New England Journal of Medicine and are scheduled for presentation at the European Society for Medical Oncology congress this weekend. Moderna and Merck released detailed trial data after an earlier leak of results prompted market moves for Moderna. If regulators and guideline panels accept the data, the combination could change adjuvant treatment for patients at high risk of melanoma returning.

Ana Marie Cox
@anamariecox.com

Enormous news. A melanoma vaccine, one of the most deadly cancers out there. Science is good and helpful and there should be more of it. www.washingtonpost.com/health/2026/...

38959h ago
Quoting this
Adam Holisky115

There’s details in this that are notable, but overall absolutely amazing. I imagine most of us will eventually know someone who’s life was saved because of this. Star Trek level technology here.

🐾 ᓚᘏᗢ Frollein Cortex ᗢᘏᓗ 🐾37

Was für ein Erfolg! 💪🏻 Überall Erfolge bei der Individualmedizin. Nur doof, dass man jetzt überall an der Prävention sparen will 🤔

magpie TRICKS26

Holy shit. I had a coworker who died of melanoma. Was in his late 30s with young kids. This could be so huge

TheSarapocalypse24

Some actual good news for the day!! I was lucky to catch my melanoma at stage 2 as it was handily visible on my forearm, but so many others aren't. AoNZ has the highest rates in the world due to our location, lack of prevention priority and she'll be right attitude. Thus will be a game changer.

Catherine Frieman21

This is 100% a bfd (especially for archaeologists who spend a tin of time outside!)... but also why does the moderna sign in this photo look like it's got tesco branding??

Shannon Waters21

I don't know what to make of the fact we're entering the era of increasing evidence of effective cancer vaccines at a time of increasing vaccine skepticism

Scott McGrath20

🧪 Once again, vaccines are amazing! I have no doubt anti-vax will end up in the dustbin of history, viewed as the modern equivalent of tobacco smoke enemas (once thought to revive drowning victims in the 1700s). Absolute lunacy in the face of actual miracles. #MedSky 🛟

Nor Bert18

„In meinen Körper kommt keine mRNA.“ 🤡

David Olsen12

Give it to every Australian.

Eb9

Great news. Awkward lede considering the coronavirus pandemic isn't actually over, but. Great news.

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